abstract：:Serum phospholipids were analyzed for their content of long-chained fatty acids together with other components of lipoproteins (total- and HDL-cholesterol, apolipoproteins A-I and B, triglycerides), in 60 coronary heart disease patients and 30 control individuals. Some of the individual variations in content of the va...

journal_title：Atherosclerosis

authors： Aursnes I,Smith P,Christiansen EN,Berg K

更新日期：1988-02-01 00:00:00

abstract：:Low density lipoproteins extracted from surgical specimens of human atherosclerotic plaques (A-LDL) showed altered electrophoretic mobility indicating a greater negative charge than that of plasma LDL (P-LDL). A-LDL but not P-LDL showed high affinity binding/degradation by human monocyte-derived macrophages; this was ...

journal_title：Atherosclerosis

authors： Shaikh M,Martini S,Quiney JR,Baskerville P,La Ville AE,Browse NL,Duffield R,Turner PR,Lewis B

更新日期：1988-02-01 00:00:00

abstract：:Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no l...

journal_title：Atherosclerosis

authors： Kritchevsky D,Tepper SA,Klurfeld DM

更新日期：1988-01-01 00:00:00

abstract：:The levels, isoforms and distribution of apolipoprotein A-IV (apo A-IV) were investigated in 127 term human umbilical cord sera. In addition, apo A-IV levels and isoforms were determined on the 3rd (n = 82) and 6th (n = 68) day following parturition and compared to apo A-I concentrations. Levels of apo A-IV were low i...

journal_title：Atherosclerosis

authors： Steinmetz A,Czekelius P,Thiemann E,Motzny S,Kaffarnik H

更新日期：1988-01-01 00:00:00

abstract：:Serum concentrations of lipoproteins, apolipoprotein A-I (Apo A-I), androgens, including biologically active free testosterone (free T), and sex hormone binding globulin (SHBG) and their associations were studied in 3 groups of men of different physical fitness and risk of CHD, consisting of male CHD patients, joggers...

journal_title：Atherosclerosis

authors： Hämäläinen E,Tikkanen H,Härkönen M,Näveri H,Adlercreutz H

更新日期：1987-10-01 00:00:00

abstract：:Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 ...

journal_title：Atherosclerosis

authors： Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

更新日期：1987-10-01 00:00:00

abstract：:Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Marshall MW,Kliman PG

更新日期：1987-08-01 00:00:00

abstract：:83 pairs of twins, aged 50-74 years, were studied with respect to their serum apoproteins (A-I, A-II, B, C-II, C-III and E) and cholesterol concentrations. Each of the variables showed a higher intraclass correlation in the MZ twins than in the DZ twins. HDL cholesterol showed the highest intraclass correlation among ...

journal_title：Atherosclerosis

authors： Hayakawa K,Shimizu T,Ohba Y,Tomioka S

更新日期：1987-07-01 00:00:00

abstract：:The present study is the first work to evaluate thrombin-, ADP-, and collagen-induced platelet aggregation in laboratory rats receiving alimentation with the parenterally-administered lipid emulsion, Lipofundin-S, in doses sufficient to induce early atherosclerotic changes in the aorta. The aggregometry parameters of ...

journal_title：Atherosclerosis

authors： Saladino CF,Fox RL,Yeh Q,Karpowicz F,Feffer SE,Jonas EA

更新日期：1987-07-01 00:00:00

abstract：:The differences in the fatty acid spectra of serum samples obtained from vegetarians (62 females, 40 males) and non-vegetarians (70 females, 38 males) were evaluated in a matched-pair study design. This study population made it possible to examine 48 female and 31 male pairs whose age difference did not exceed 3 years...

journal_title：Atherosclerosis

authors： Melchert HU,Limsathayourat N,Mihajlović H,Eichberg J,Thefeld W,Rottka H

更新日期：1987-05-01 00:00:00

abstract：:In monocyte-derived macrophages from both normal and familial hypercholesterolaemic (FH) subjects, degradation of low density lipoprotein (LDL) through non-saturable pathways produced the same fall in 3-hydroxy-3-methylglutaryl-CoA reductase activity as receptor-mediated degradation of acetylated LDL, yet did not lead...

journal_title：Atherosclerosis

authors： Knight BL,Soutar AK,Patel DD

更新日期：1987-04-01 00:00:00

abstract：:The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...

journal_title：Atherosclerosis

authors： Glick JM,Adelman SJ,Rothblat GH

更新日期：1987-04-01 00:00:00

abstract：:Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying le...

journal_title：Atherosclerosis

authors： Skarlatos SI,Hollis TM

更新日期：1987-03-01 00:00:00

abstract：:The effect of an acute exercise session on high density lipoprotein-cholesterol (HDL-C) and the subfractions HDL2-C and HDL3-C was determined for 9 healthy females (VO2max = 46.62 +/- 4.82 ml X kg-1 min-1). Each subject underwent a continuous 40-min run on a treadmill at a workload corresponding to 70% of VO2max. A ve...

journal_title：Atherosclerosis

authors： Swank AM,Robertson RJ,Deitrich RW,Bates M

更新日期：1987-02-01 00:00:00

abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...

journal_title：Atherosclerosis

authors： Thiery J,Seidel D

更新日期：1987-01-01 00:00:00

abstract：:The relationships among platelet membrane fluidity, arterial thrombosis tendency, and platelet aggregation and prostanoid formation were investigated after feeding rats diets enriched in (n-6) or (n-3) polyunsaturated fatty acids. For at least 8 weeks, rats were fed a control diet containing 5 energy % (en%) sunflower...

journal_title：Atherosclerosis

authors： Rand ML,Hennissen AA,Hornstra G

更新日期：1986-12-01 00:00:00

abstract：:Even when administered at a comparatively low level, dietary cholesterol produces significant changes in the properties of plasma lipoproteins in rats, particularly the d less than or equal to 1.006 g/ml fraction (VLDL). The occurrence of these changes is promoted by dietary casein. To test the hypothesis that these d...

journal_title：Atherosclerosis

authors： Eklund A,Sjöblom L,Ostlund-Lindqvist AM

更新日期：1986-11-01 00:00:00

abstract：:The role of endothelial cells (EC) in the development and progression of early swine intimal cell mass (ICM)-derived coronary artery lesions in 55 swine fed either a mash or hyperlipidemic diet for 14, 49 or 90 days was investigated. Characteristics studied were endothelial cell turnover (using tritiated thymidine aut...

journal_title：Atherosclerosis

authors： Scott RF,Kim DN,Schmee J,Thomas WA

更新日期：1986-10-01 00:00:00

abstract：:Apolipoprotein B (apoB) release from activated washed human platelets was measured by enzyme-linked immunosorbent assay (ELISA) using monospecific rabbit antibodies to human low density lipoprotein (LDL). Activation of platelets with thrombin, Ca2+-ionophore A23187 or stable analogue of prostaglandin endoperoxides U46...

journal_title：Atherosclerosis

authors： Preobrazhensky SN,Podrez EA,Tsibulsky VP,Fuki IV,Mazurov AV,Repin VS,Smirnov VN

更新日期：1986-09-01 00:00:00

abstract：:Sitostanol (24-ethyl-5 alpha-cholestan-3 beta-ol), a hydrogenated derivative of sitosterol, was administered in a low dose (1.5 g/day) for 4 weeks to 6 patients with hypercholesterolemia. Total cholesterol was reduced significantly after 3 and 4 weeks by 10 and 15%, respectively. The reduction of total cholesterol was...

journal_title：Atherosclerosis

authors： Heinemann T,Leiss O,von Bergmann K

更新日期：1986-09-01 00:00:00

abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

journal_title：Atherosclerosis

authors： Saito H,Salmon JA,Moncada S

更新日期：1986-08-01 00:00:00

abstract：:Thirty-nine synthetic (32 Dacron and 7 Teflon) arterial prostheses (from 38 patients with peripheral arterial disease) removed after periods between 2 months and 18 years, were examined by histology and immuno-histology. The grafts were initially permeated by thrombus containing platelet antigens and this became organ...

journal_title：Atherosclerosis

authors： Walton KW,Slaney G,Ashton F

更新日期：1986-08-01 00:00:00

abstract：:Skinfold thickness, % body fat content, body mass index, systolic and diastolic blood pressure, plasma glucose, serum cholesterol and triglycerides have been measured in 132 middle-aged men (mean age 39.8 +/- 9.9, range 20-59 yr) and in 114 middle-aged women (mean age 39.1 +/- 9.3, range 20-59 yr). Anthropometric data...

journal_title：Atherosclerosis

authors： Contaldo F,Di Biase G,Panico S,Trevisan M,Farinaro E,Mancini M

更新日期：1986-08-01 00:00:00

abstract：:Five out of 15 homozygotes and 41 out of 527 heterozygotes of familial hypercholesterolemia (FH) died during the past 10 years. Sudden death or heart failure was the cause of death in each of the 5 deceased homozygotes. Twenty heterozygotes died of myocardial infarction, 9 of sudden death, and 1 died after AC bypass s...

journal_title：Atherosclerosis

authors： Mabuchi H,Miyamoto S,Ueda K,Oota M,Takegoshi T,Wakasugi T,Takeda R

更新日期：1986-07-01 00:00:00

abstract：:The ranges for near-threshold ADP concentrations for the aggregation of macaque and human citrated platelets overlapped. The minimum concentrations of epinephrine, 0.05 microM to 1.0 microM, that at least doubled the aggregation response at threshold ADP concentrations were comparable for macaque and human citrated pl...

journal_title：Atherosclerosis

authors： Beatty CH,Howard CF Jr,Caruso V

更新日期：1986-05-01 00:00:00

abstract：:When smoke from single cigarettes containing [4-14C]cholesterol or beta-[4-14C]sitosterol was delivered to the lungs of Rhesus macaques, plasma contained radiolabeled sterols up to 50 days later. Since cholesterol, as well as plant sterols (campesterol, stigmasterol and beta-sitosterol), are normally present in cigare...

journal_title：Atherosclerosis

authors： Malinow MR,McLaughlin P,Aigner-Held R,Upson B,Isabelle LM,Connor WE,Lin D

更新日期：1986-04-01 00:00:00

abstract：:The heavy and light subfractions of low density lipoprotein (LDL) were bound to the same extent and with the same affinity by the LDL receptors of cultured human fibroblasts, both when assayed at 4 degrees C and when assayed at 37 degrees C. They were also degraded similarly by the low affinity, LDL-receptor-mediated ...

journal_title：Atherosclerosis

authors： Knight BL,Thompson GR,Soutar AK

更新日期：1986-03-01 00:00:00

abstract：:The concentrations of cholesterol (C) and phospholipid (PL) levels in the high density lipoprotein (HDL) fraction and the HDL2 and HDL3 subfractions were determined in 74 men with incapacitating angina pectoris and coronary artery disease (CAD) verified by angiography. An equal number of randomly sampled healthy men m...

journal_title：Atherosclerosis

authors： Wallentin L,Sundin B

更新日期：1986-02-01 00:00:00

abstract：:Twelve subjects (6 women, 6 men) were given 120 g fat orally for 2 h to study its effect on serum high density lipoproteins (HDL), HDL subfractions and apoproteins A-I and A-II. In addition, we measured the fasting activity of adipose tissue lipoprotein lipase (LPL). The HDL2 mass concentration increased significantly...

journal_title：Atherosclerosis

authors： Taskinen MR,Kuusi T

更新日期：1986-02-01 00:00:00

abstract：:Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...

journal_title：Atherosclerosis

authors： Antonov AS,Nikolaeva MA,Klueva TS,Romanov YuA,Babaev VR,Bystrevskaya VB,Perov NA,Repin VS,Smirnov VN

更新日期：1986-01-01 00:00:00

abstract：:In an earlier study of swine fed hyperlipidemic (HL) diets containing either butter or corn oil we found wide differences in atherogenic intimal proliferative responses among the swine, especially in the corn oil group, that could not be entirely accounted for by differences in serum cholesterol levels. We hypothesize...

journal_title：Atherosclerosis

authors： Kim DN,Geourzoung SM,Schmee J,Lee KT,Thomas WA

更新日期：1985-12-01 00:00:00

abstract：:Five homozygous patients with familial hypercholesterolemia (FH) are described. Their serum cholesterol levels were between 603 and 907 mg/dl, with an average of 714 mg/dl. The mean value of serum cholesterol levels of the obligate heterozygous parents was 270 mg/dl. In the patient group, 87% of the serum cholesterol ...

journal_title：Atherosclerosis

authors： Cai HJ,Fan LM,Huang MG,Chen XY,Liu GQ,Chen Q

更新日期：1985-11-01 00:00:00

abstract：:Laying and genetically defective non-laying hens were evaluated for plasma lipid and plasma peroxidation levels. The non-layers developed extreme hyperlipidemia as well as greatly increased levels of lipid peroxidation. It was concluded that the concurrent presence of lipid peroxidation products must be considered whe...

journal_title：Atherosclerosis

authors： Smith T,Toda T,Kummerow FA

更新日期：1985-10-01 00:00:00

abstract：:When rabbits are fed a cholesterol-rich diet they accumulate beta-migrating very low density lipoprotein (beta-VLDL) in their plasma. beta-VLDL are cholesteryl ester-rich lipoproteins which contain apolipoproteins B and E. There are 2 forms of apolipoprotein B in beta-VLDL. About 90% of apolipoprotein B is present as ...

journal_title：Atherosclerosis

authors： Kroon PA,Thompson GM,Chao YS

更新日期：1985-09-01 00:00:00

abstract：:Topographic distribution of atherosclerotic lesions of the aortic valve was investigated in rabbits on a 2%-cholesterol-enriched diet and related to distribution of intramural stress in the valve. Initially the lesions appeared at the base of the leaflet on the aortic face and with time spread further out into the lea...

journal_title：Atherosclerosis

authors： Thubrikar MJ,Deck JD,Aouad J,Chen JM

更新日期：1985-06-01 00:00:00

abstract：:Bezafibrate in a dosage of 200 mg 3 times daily was given to 24 patients with type II A (n = 8), II B (n = 1) and IV (n = 15) hyperlipoproteinaemia for 4.5 years. In type II A the content of total cholesterol and that of low density lipoprotein in serum decreased by 10-23 and 11-34 percent over the years compared to p...

journal_title：Atherosclerosis

authors： Olsson AG,Lang PD,Vollmar J

更新日期：1985-05-01 00:00:00

abstract：:29 autogenous vein grafts, from 26 patients with peripheral arterial disease, were studied. 4 grafts of Group I (less than 3 months duration) were patent and removed for reasons other than graft failure. These showed 'arterialisation' only; 4 grafts of Group II (duration 5-18 months) showed thrombotic occlusion; 21 gr...

journal_title：Atherosclerosis

authors： Walton KW,Slaney G,Ashton F

更新日期：1985-01-01 00:00:00

abstract：:In view of hypotheses suggesting mutagenesis is implicated in atherosclerosis, a total of 18 lipid extracts of human aortal tissues was examined by the standard Ames mutagenicity bioassay using Salmonella typhimurium or by a liquid modification thereof. One lipid extract of intimal-medial tissue contained detectable m...

journal_title：Atherosclerosis

authors： Johnson BH,Smith LL

更新日期：1984-12-01 00:00:00

abstract：:Hypothyroidism is associated with hypercholesterolemia and increased risk for atherosclerotic disease. The European badger exhibits large seasonal changes in thyroid activity and the annual minimum of plasma thyroxine level in this species occurs at the same period of the year (i.e. late fall) as a pronounced hypercho...

journal_title：Atherosclerosis

authors： Laplaud PM,Beaubatie L,Maurel D,Catanzano G

更新日期：1984-11-01 00:00:00

abstract：:The effect of prostaglandins (PG) on initiation of DNA synthesis in arterial smooth muscle cells (SMC) stimulated with platelet-derived growth factor (PDGF) was examined. A concentration of 10 ng/ml PGE1 inhibited DNA synthesis, measured as autoradiographically labeled nuclei, by about 70%. Similar results were obtain...

journal_title：Atherosclerosis

authors： Nilsson J,Olsson AG

更新日期：1984-10-01 00:00:00